Theme: At the JC, we will discuss an article reporting a RCT of Intravenous Immunoglobin (IVIG) for treatment of psychiatric symptoms in children with Pediatric Autoimmune Neuropsychiatric Disorders Associated With Streptococcal Infections (PANDAS). The proposed autoimmune pathogenesis of PANDAS opens up possibilities of novel treatment options such as IVIG for psychiatric symptoms, but does treatment with IVIG work? IVIG treatment is uncommon, but is in clinical use in Sweden today. In the JC we will discuss the trial and its outcomes and possible methodological issues of the study. We will also discuss an editorial commenting on the paper. The JC will be held in English.

Related editorial: Intravenous Immunoglobulin Is Not an Effective Treatment for Pediatric Autoimmune Neuropsychiatric Disorder Associated With Streptococcal Infection Obsessive-Compulsive Disorder (Mink, 2016)

Faculty Discussant: Lorena Fernandez de la Cruz, Assistant Professor at CNS